The COVID-19 pandemic has demanded a huge effort to identify the risks associated
with poor outcomes. The focus has been particularly relevant in patients with immune-mediated
inflammatory diseases and those on therapies that suppress the immune system. Small
early observational studies looked worrisome, but as data from larger studies became
available a consistent picture became evident. Demographic risk factors such as age
and comorbidity are really the salient factors, with some risk from underlying disease
and a few specific therapeutic agents, such as rituximab.
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