Drug repurposing or repositioning is a technique whereby existing drugs are used to
treat emerging and challenging diseases, including COVID-19. Drug repurposing has
become a promising approach because of the opportunity for reduced development timelines
and overall costs. In the big data era, artificial intelligence (AI) and network medicine
offer cutting-edge application of information science to defining disease, medicine,
therapeutics, and identifying targets with the least error. In this Review, we introduce
guidelines on how to use AI for accelerating drug repurposing or repositioning, for
which AI approaches are not just formidable but are also necessary.

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