Drug repurposing or repositioning is a technique whereby existing drugs are used to

treat emerging and challenging diseases, including COVID-19. Drug repurposing has

become a promising approach because of the opportunity for reduced development timelines

and overall costs. In the big data era, artificial intelligence (AI) and network medicine

offer cutting-edge application of information science to defining disease, medicine,

therapeutics, and identifying targets with the least error. In this Review, we introduce

guidelines on how to use AI for accelerating drug repurposing or repositioning, for

which AI approaches are not just formidable but are also necessary.

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